SSI Biology Unveils New DNA Synthesizer Design

How do you construct the first ever DNA synthesizer to operate in space?

This is the challenge that Stanford SSI’s brand new Biology team is tackling as it races to complete a functional device by the end of Spring Quarter. Controlling temperature, ensuring that all reagents needed for the addition of nucleotides to a single strand of DNA are compatible, and verifying that the scientific endeavor was successfully completed is no simple task. To tackle this difficult task, SSI Biology created a minimally viable product (MVP) design it had the pleasure of unveiling at the Uytengsu Teaching Lab Spring Showcase.

The device design is simple, compact and elegant.

The core of the minimally viable product design is a clear, biosafe plastic container for our DNA synthesis reagents, which include the enzyme that builds the DNA strand and a complementary single DNA strand that will bind to our product. This capsule will be encased in aluminum for temperature regulation, using Peltier modules or another heat source to activate the synthesis reaction. An LED and a photodiode will be focused on the synthesis chamber, exploiting the fluorescence of chemicals that bind to DNA to determine that the DNA sequence was elongated.

This design was unveiled on April 13th at the Uytengsu Teaching Lab Spring Showcase, an opportunity for undergraduate student groups to present to faculty, students, representatives from DNA synthesis companies and NASA researchers. We had the privilege of learning from experts in the field the difficulties that we will surely face as we approach a launch, as well as gaining technical feedback that our members are presently incorporating into the design. 

As far as we have come, there is undoubtedly still a lot to be done. If you would like to be involved or have questions about this project, please contact co-leads Alan Tomusiak ([email protected]) and Cynthia Hao ([email protected]).

We would like to extend a special thanks to the Uytengsu Teaching Lab managers, Mong Saetern and Jeffrey Tok, without whom this presentation would not have been possible.

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IREC Test Launch at FAR

This past Saturday, April 16th, the IREC team on Rockets made a journey down to the launch site owned and operated by the Friends of Amateur Rocketry (FAR) near Mojave, CA. It was a long car ride there and back, but it was well worth getting a chance to test the rocket design that we will ultimately take with us to New Mexico for the Spaceport America Cup in June.
From left to right: Saylor Brisson, Marie Johnson, John Dean, Rushal Rege, Logan Herrera, Ian Gomez, James Kolano, William Alvero-Koski, Derek Phillips, Christopher May, Thomas White, Rebecca Wong, Shi Tuck, Ruqayya Toorawa

Although we only managed to get one flight of our rocket in, we were very pleased with the opportunity to test all of our basic systems, from the deployment mechanism for our payload, to our motor retention system, to our SRAD avionics and beacon + GPS tracking. All of our sub-teams learned a lot from the journey and were excited that we got to return home with all of our components in-tact and recovered! We're looking forward to our next test launch when we return with various tweaks and improvements.

Some additional bonuses to the trip were getting to meet the Cal Poly team and watch their rocket have a beautiful flight, and getting a chance to chat with some local middle school students about our project! Lastly I'd like to make a large shout-out to Eric Melville for his continuous support as we progress through our project. He's been a wealth of guidance and information both on and off the launch site. Thank you, Eric!Lift Off!

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Vibration test at Quanta Labs

On Tuesday, March 7th, members of our rockets Intercollegiate Rocket Engineering Competition (IREC) team visited Quanta Labs to perform a vibration test of our avionics system. Our unit passed the test. No major problems were detected, but we did gain insight into how to make our avionics system even more vibration and shock tolerant.

The Avionics System:
The avionics system in our rocket for IREC has been designed for high-reliability using redundant commercial altimeters and a custom student researched and developed flight computer. Its main function is to trigger deployment of the payload and recovery parachutes. In addition, the unit provides an RF beacon for locating the rocket after landing and a telemetry stream of live flight data using an RF link. Thanks to our recent sponsorship from Harwin, our avionics system features high-reliability connectors in important, safety critical connections.

The Test:
The unit that we tested included the parachute deployment assembly and avionics. This full assembly sat inside a sample section of our in-house custom fiberglass and carbon fiber airframe. To fixture our airframe section to the shake table, a CNC’ed delrin clamp was bolted into the shake table.
Integration of the system on the shake table

Using a shaker table at Quanta Labs, we performed the following tests of the system 
  1. 30G 6ms positive direction per axis, 3 axes
  2. 30G 6ms negative direction per axis, 3 axes
  3. 10Grms thrust axis 20Hz - 2kHz 20 seconds
  4. 7.6Grms lateral axes 20Hz - 2kHz 20 seconds each

The test specifications came from two sources. For shock, we used real values that we had recorded on previous flights. For vibration, we used the specs from the NASA Sounding Rockets User Handbook - Vehicle Level 1. These vibration specs are used to qualify payloads for going to space on NASA sounding rockets.

Here is a plot of the spectral content of the vibration applied for one of the tests:

To measure the continuity of the ignition lines from the avionics bay during the vibration and shock tests, we used one of our Keysight oscilloscopes, and recorded a 30 second session of the voltage across all of the lines.Our Keysight Oscilloscope used for recording ignition line continuity during the test

Here are some other pictures from our testing:Overhead view of the shake table

Connections for the test

We owe a huge thanks to Quanta Labs for providing their facilities and time to allow us to perform this test. Vibration and shock testing is critical for safety and reliability, and would not be possible without our sponsors.

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A Cosmic Perspective

Humans have always been fascinated with space and what might be out there, especially the possibility of finding another intelligent species. We do not often, however, consider the ethical implications of reaching out to such a species. As technology to listen, and perhaps broadcast, to further and further away places advances, the debate over the ethics of making contact with extraterrestrial life becomes increasingly important. Should we be trying to communicate with other species that might exist in space? If so, what should we be saying? Who should be deciding what our message should be? We spoke with Jill Tarter, Pete Worden, and David Brin to learn more about the search for extraterrestrial intelligence and the ethical and policy issues that surround it.

Dr. Jill Tarter is the former director of the Center for SETI Research. She has spent her entire professional career on SETI and is easily the best-known SETI scientist. She graduated from Cornell and went on to get her PhD from UC Berkeley. Since graduate school, she has been involved in various SETI-related projects. She was the Project Scientist for the NASA High Resolution Microwave Survey and later lead Project Phoenix. She is also an adviser to the Breakthrough Prize Foundation's Breakthrough Listen initiative.

Dr. Pete Worden is the Chairman of the Breakthrough Prize Foundation and the former Director of NASA’s Ames Research Center. He got his PhD in Astronomy from the University of Arizona and then served in several positions within the US Air Force, including Commander of the 50th Space Wing. He served twice in the Executive Office of the President. He was later a Research Professor at the University of Arizona before joining NASA. He has been a strong proponent of small satellite technology and of exploration beyond our solar system and is well known for speaking his mind, even on controversial topics.

Dr. David Brin is an award-winning author, scientist, and futurist. He has written 16 science fiction titles, including New York Times bestsellers and Hugo award winners. He has also published three nonfiction books. He serves on the external advisory board of NASA's Innovative and Advanced Concepts program. 

Why should the general public care about SETI?

Jill Tarter and Pete Worden agree on the fundamental importance of searching for extraterrestrial life, however they see the motivation somewhat differently. To Dr. Worden, it is about striving to understand our universe. Only by continuing to explore and probe deeper into space can we answer fundamental questions about the world we live in.

PW:  It is, in my opinion, a fundamental question of science. There’s two of them, and they’re both metaphysical questions: one is the origin and structure of the universe. And the other one is the origin and evolution of life. I can’t think of more fundamental science questions. And both of them relate to religious concepts. In fact religion and spiritualism is an attempt to answer those. And I think an equally legitimate one is science.  They really need to go hand-in-hand. These are the fundamental philosophical questions of humanity, they’re not sort of esoteric distant questions. They’re on your mind from the moment you become aware to the moment when you cease to be aware, I think. Maybe at the moment you cease to be aware they’re even more important. 

To Dr. Tarter, however, there’s a more human-focused motivation for the project: finding ways to foster collaboration among all of humanity. Searching for other intelligent life is not just about the life we might find, but about better understanding ourselves and learning how to see ourselves as Earthlings rather than nationals of any specific country.

JT: Are we or are we not going to have a long future on this planet? There are lots of ways we can see the answer to that is no. It seems we are doing everything in our power to trash the place, and we find all of these trivial differences amongst humans to shed blood. I think that thinking about who we are in the context of this one planet and being an Earthling as opposed to a Californian or an American or Sudanese or South African or whatever is a very important step in the maturation of the human species. 

Something else out there that coevolved with a totally different planet than ours is going to be fantastically different than we are. The idea of thinking about life somewhere else, looking for it, it has the effect of holding up a mirror to all of us on this planet. It says, “look in that mirror. You're all the same when compared to something totally independently evolved out there.” So I think it has this ability to trivialize differences that we find so divisive. I think if any current scientific endeavor should be global, I think it's SETI because a signal is not being sent to California. It’s arriving at the whole planet, and it’s the property of all of humankind. I think SETI is the perfect vehicle for trying to get people whose daily lives are different to cooperate together on a project that isn't threatening.

It's a good practice for the type of global collaboration and cooperation that were going to have to develop in order to maintain the planet and limit the population so that we can perhaps enjoy a long future. I think SETI is a good way to get people to open their eyes, think outside of the box. More cosmic perspective helps.

Of course, these are not the only arguments for the search. Dr. Worden is also motivated by what has motivated explorers for centuries - curiosity and the desire for adventure.

PW: If I said this before I’ll say it again – I think the solar system’s boring, there’s no aliens. There might not even be any life! But I’ve always had a very strong interest in nearby solar systems.

Dr. Brin argues that we should see it more like keeping watch for anyone who might show up nearby.

DB: Civilization has been all about expanding horizons. Looking outward to the next opportunity or the next danger. Only then can you get at least a little bit of lead time to prepare. It's entirely practical.

Should we send a message?

To date, with one exception, humanity’s efforts have been directly exclusively on passively listening for signals. One significant division even within strong advocates of searching for extraterrestrial life is whether humanity should be broadcasting our own messages in the hopes that another advanced civilization would detect them and respond. Most of our passive searching relies on the hope that other civilizations would are taking an active approach, as any messages not intentionally broadcast to us would likely be too weak to detect. While Dr. Worden says he has no position yet on broadcasting messages, he described the most compelling arguments on each side.

Our history has been one of conflict, and the stakes are higher today than they ever have been. We have the power to destroy our planet through war or pollution. Dr. Worden says an advanced civilization may have figured out how to get past this stage, and could guide us.

PW: A suitably advanced civilization is one that would probably have figured out how to have gotten through a conflict stage, may have a lot to teach us. So we ought to attract their attention and talk to them.

Dr. Worden points out that there’s no guarantee a decision to not send a message would be universally respected. Then the voice of humanity becomes whoever takes it upon themselves to be the voice.

PW: If we said we’re not going to do it, you might have somebody deciding that they’re gonna do it, [and] I think that this is really a question that needs to have a global democratic decision.

The possibility that someone could take it upon themselves to send a message without the consent of anyone else raises a complicated ethical and policy issue. There exists no technical capability to prevent an individual from broadcasting a message and a motivated individual could almost certainly find a nation that would not attempt to stop them. Considering the potential consequences of sending a message, this is a risk that must be taken seriously.

Arguing against sending a message, Dr. Tarter explains that any aliens in our interstellar neighborhood will likely be more advanced than us, and says we should wait and listen rather than rashly broadcast a message. 

JT: The sun is a late generation star, so anybody nearby has had a good head start. As the youngest kids that can participate in this exploration, I think it behooves us to listen first, and it's statistically hugely improbable that our first contact will also be theirs. Statistically speaking, they will be older and have done this before, so they have probably tried a number of things and might have a better idea of what works best. So why don't we listen, see what they're doing, and follow that lead rather than deciding “Oh I'm here now, and we're going to do it this way and only decide to do it for a year because my species just can't manage to get its act together for longer than that.”

Dr. Worden acknowledges this argument and expands upon it further, pointing out the risk that other civilizations could intend us harm.

PW: One side of the argument is the obvious one that attracting attention with a potentially hostile civilization—especially if it’s nearby—as we think about going between stars, maybe they can figure out how to do that already or could—is that the chances are that if we detected their signal they’re probably more advanced than we are—that we may attract the attention of a hostile civilization, that they may come here and do horrible things. There are thousands of science fiction books and movies—some of the most dramatic ones are nasty aliens. That is a strong argument that says you should be very careful about sending things.

Above all, both Dr. Tarter and Dr. Worden emphasized the importance of a global process for decisions on what, if any, message to send and how we might respond to an incoming message. Because whoever sends a message is effectively speaking for all of humanity, it is extremely important that there is some global process that gives everyone some input into these decisions.

PW: I think the number one ethical issue is—it’s a political as well ethical issue—is who speaks for Earth. And how does one do that. [...] I’m not an opponent nor an advocate [of broadcasting a message]. I’m an advocate for humanity carefully deliberating on it. One day I’ll wake up and think we ought to send things, another day maybe we shouldn’t. I think the arguments all come down to the issue is who is speaking for me. Me as a collective me.

JT: [Sending a message is] something that we've been formally been taking a look at in the International Academy of Astronautics. There's a post detection protocol that we wrote in the 80s in the height of the Cold War about this question. There's an Article 8 that talks about the signators agree not to reply to any detected message until there's some global consensus. That doesn't really help you a lot, it doesn't tell you how you're going to get that sort of thing, but the idea is to discuss in advance whether a message should be sent, and if so, who would speak for Earth and what should they say. What would you want the message to be? To answer what message, I think it really needs to be crowdsourced. It needs to come from the world's population with as much representation of all kinds of different belief systems and traditional ideas as we can.

Dr. Brin draws upon the movie adaptation of Heinlein's Starship Troopers to illustrate that even if contact with alien life unifies humans, it won’t make us better people. He thinks expanding our horizons won’t decrease worry and fear, only redirect it at another target. 

DB: If you look at the human characters [in Starship Troopers]  they are free.. and everybody is encouraged to know as much as they want. And argue as much as they want. And you remember the scene in which the guys, the gals are all showering together? The commander of all human forces is this short, dumpy black woman. Clearly we have overcome all of our old internal bitchinesses and bigotries. And are we nice people? No. We’re fucking assholes. We’re pounding our way across the galaxies and we started that war. You see how that illustrates this process of horizons expansion.


If there’s a common theme to Dr. Tarter’s, Dr. Worden’s, and Dr. Brin’s comments, it is that the search for extraterrestrial life is more about humanity than it is about the actual extraterrestrial life. Dr. Worden and Dr. Tarter are both more concerned about the way that humanity will respond than anything else. To Dr. Tarter, part of the point for looking beyond the Earth is to understand that humanity is collectively all in this together. In this way, she echos Dr. Brin’s argument that we never let go of fear, we only move out the horizon on which we look. But in moving out this horizon beyond earth, it becomes possible to set aside our internal conflicts.

Dr. Worden brings up the most complicated policy issue: when any individual actor anywhere in the world could take it upon themselves to send a message that speaks for all of humanity, how do you build and enforce consensus across not just a nation but across all of humanity?

These are questions that even three leading experts have no good answers to. But, as we continue to listen to our universe, there is no way to know when humanity might be forced to confront this challenge. Even if no one decides to broadcast a message again, there will always be the possibility that another intelligent species contacts us. One way or another, humanity will eventually have to confront the question of how to send or respond to messages. As Dr. Worden points out, it is important that this conversation begin long before a message is sent or received.

Derek Phillips, Thomas Teisberg, Bang Nguyen, Justin Adamson

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Last Thursday, February 16, a few members of SSI loaded a rocket, an optical communications transmitter, and the world-record breaking SSI-47 ValBal into a ZipCar to head to Dartmouth Middle School for their annual STEM science fair.

The Education and Outreach team had a great time discussing our current progress and goals for SSI as an organization and for the individual teams with students, parents, and teachers alike. While SSI is an organization that is constantly looking up, opportunities like these allow us to bring others along for the ride as kids in NASA shirts and former industry representatives alike join us for a brief time in exploring our shared passions.

While Dartmouth's STEM fair was a great chance for SSI to be involved with the community beyond Stanford, it also served as great practice for the booth we plan to have at the 2017 Bay Area Maker Faire from May 19-21. We hope to continue to reach out and inspire as we push further up and away from the world on the ground!

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